1NZQ

D-Phe-Pro-Arg-Type Thrombin Inhibitor

1NZQ の概要

• エントリーDOI: 10.2210/pdb1nzq/pdb
• 関連するPDBエントリー: 1A5G 1O0D 1PPB
• 関連するBIRD辞書のPRD_ID: PRD_000480
• 分子名称: Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total)
• 機能のキーワード: thrombin, thrombin inhibitor, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35847.90

構造登録者

Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (登録日: 2003-02-19, 公開日: 2003-10-14, 最終更新日: 2025-03-26)

主引用文献

Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety
Bioorg.Med.Chem.Lett., 13:2029-2033, 2003

PubMed Abstract: Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.

PubMed: 12781189
DOI: 10.1016/S0960-894X(03)00236-1

実験手法

X-RAY DIFFRACTION (2.18 Å)