1NZ7

POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.

1NZ7 の概要

• エントリーDOI: 10.2210/pdb1nz7/pdb
• 関連するPDBエントリー: 1NL9 1NNY 1No6 1ONY 1ONZ
• 分子名称: Protein-tyrosine phosphatase, non-receptor type 1, 2-[(4-{2-ACETYLAMINO-2-[4-(1-CARBOXY-3-METHYLSULFANYL-PROPYLCARBAMOYL)-BUTYLCARBAMOYL]-ETHYL}-2-ETHYL-PHENYL)-OXALYL-AM INO]-BENZOIC ACID (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase fold, oxamic acid inhibitor bound to p-loop, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38038.38

構造登録者

Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G. (登録日: 2003-02-16, 公開日: 2003-05-20, 最終更新日: 2023-08-16)

• 主引用文献: Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G.; Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B; BIOORG.MED.CHEM.LETT., 13:1887-1890, 2003; PubMed: 12749891; DOI: 10.1016/S0960-894X(03)00302-0

実験手法

X-RAY DIFFRACTION (2.4 Å)