1NYD
Solution structure of DNA quadruplex GCGGTGGAT
Summary for 1NYD
| Entry DOI | 10.2210/pdb1nyd/pdb |
| Descriptor | 5'-D(*GP*CP*GP*GP*TP*GP*GP*AP*T)-3' (1 entity in total) |
| Functional Keywords | quadruplex, parallel quadruplex, molecular propeller topology, double chain reversal, dna |
| Total number of polymer chains | 4 |
| Total formula weight | 11247.38 |
| Authors | Webba da Silva, M. (deposition date: 2003-02-12, release date: 2004-02-24, Last modification date: 2024-05-22) |
| Primary citation | Webba da Silva, M. Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT). Biochemistry, 42:14356-14365, 2003 Cited by PubMed Abstract: The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymine intersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps. PubMed: 14661946DOI: 10.1021/bi0355185 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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