1NXI

Solution structure of Vibrio cholerae protein VC0424

Summary for 1NXI

• Entry DOI: 10.2210/pdb1nxi/pdb
• NMR Information: BMRB: 5589
• Descriptor: conserved hypothetical protein VC0424 (1 entity in total)
• Functional Keywords: structural genomics, ab sandwich, cog 3076, atcc no. 51394d, nesg target op3, psi, protein structure initiative, northeast structural genomics consortium, unknown function
• Biological source: Vibrio cholerae
• Total number of polymer chains: 1
• Total formula weight: 15341.78

Authors

Ramelot, T.A.,Ni, S.,Goldsmith-Fischman, S.,Cort, J.R.,Honig, B.,Kennedy, M.A.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2003-02-10, release date: 2003-07-01, Last modification date: 2024-05-08)

Primary citation

Ramelot, T.A.,Ni, S.,Goldsmith-Fischman, S.,Cort, J.R.,Honig, B.,Kennedy, M.A.
Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold.
Protein Sci., 12:1556-1561, 2003

PubMed Abstract: The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076). The structure has an alpha-beta sandwich architecture consisting of two layers: a four-stranded antiparallel beta-sheet and three side-by-side alpha-helices. The secondary structure elements have the order alphabetaalphabetabetaalphabeta along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the beta-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins.

PubMed: 12824501
DOI: 10.1110/ps.03108103

Experimental method

SOLUTION NMR