1NWL
Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic
Summary for 1NWL
Entry DOI | 10.2210/pdb1nwl/pdb |
Descriptor | protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 3-(4-{2-[2-(2-BROMO-ACETYLAMINO)-ETHYLDISULFANYL]-ETHYLCARBAMOYL}-CYCLOHEXYLCARBAMOYL)-PYRAZINE-2-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35140.32 |
Authors | Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S. (deposition date: 2003-02-06, release date: 2003-04-01, Last modification date: 2024-02-14) |
Primary citation | Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S. Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering J.Am.Chem.Soc., 125:5602-5603, 2003 Cited by PubMed: 12733877DOI: 10.1021/ja034440c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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