1NVX

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

Summary for 1NVX

• Entry DOI: 10.2210/pdb1nvx/pdb
• Related: 1BKD 1NVU 1NVV 1NVW
• Descriptor: Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: proto-oncogene, gtp-binding, guanine-nucleotide releasing factor, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
• Total number of polymer chains: 3
• Total formula weight: 94897.52

Authors

Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. (deposition date: 2003-02-04, release date: 2003-04-01, Last modification date: 2023-08-16)

• Primary citation: Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J.; Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS; Cell(Cambridge,Mass.), 112:685-695, 2003; PubMed: 12628188; DOI: 10.1016/S0092-8674(03)00149-1

Experimental method

X-RAY DIFFRACTION (3.2 Å)