1NTX
SECONDARY STRUCTURE DETERMINATION FOR ALPHA-NEUROTOXIN FROM DENDROASPIS POLYLEPIS POLYLEPIS BASED ON SEQUENCE SPECIFIC PROTON NUCLEAR MAGNETIC RESONANCE ASSIGNMENTS
Summary for 1NTX
| Entry DOI | 10.2210/pdb1ntx/pdb |
| Descriptor | ALPHA-NEUROTOXIN (1 entity in total) |
| Functional Keywords | neurotoxin |
| Biological source | Dendroaspis polylepis polylepis (black mamba) |
| Cellular location | Secreted: P01416 |
| Total number of polymer chains | 1 |
| Total formula weight | 6928.92 |
| Authors | Brown, L.R.,Wuthrich, K. (deposition date: 1992-04-30, release date: 1994-01-31, Last modification date: 2024-10-30) |
| Primary citation | Labhardt, A.M.,Hunziker-Kwik, E.H.,Wuthrich, K. Secondary structure determination for alpha-neurotoxin from Dendroaspis polylepis polylepis based on sequence-specific 1H-nuclear-magnetic-resonance assignments. Eur.J.Biochem., 177:295-305, 1988 Cited by PubMed Abstract: Sequence-specific assignments are presented for the polypeptide backbone protons and a majority of the amino-acid-side-chain protons of alpha-neurotoxin from Dendroaspis polylepis polylepis, and individual amide proton-exchange rates with the solvent are reported. The secondary structure and the hydrogen-bonding patterns in the regular secondary structure elements are deduced from nuclear Overhauser effects and the sequence locations of the slowly exchanging amide protons. The molecule includes a three-stranded antiparallel beta-sheet, and there are indications that two additional short chain segments are arranged in an antiparallel beta-sheet. These structural elements are similar, but not identical, to either the secondary structure reported for erabutoxin b in single crystals, or the solution structure of cytotoxin CTXIIb from Naja mossambica mossambica. PubMed: 2847926DOI: 10.1111/j.1432-1033.1988.tb14376.x PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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