1NSW

The Crystal Structure of the K18G Mutant of the thioredoxin from Alicyclobacillus acidocaldarius

Summary for 1NSW

Entry DOI	10.2210/pdb1nsw/pdb
Related	1NWL 1QUW 2TRX
Descriptor	THIOREDOXIN (2 entities in total)
Functional Keywords	thermostability, thioredoxin, electron transport
Biological source	Alicyclobacillus acidocaldarius
Total number of polymer chains	4
Total formula weight	46052.65
Authors	Bartolucci, S.,De Simone, G.,Galdiero, S.,Improta, R.,Menchise, V.,Pedone, C.,Pedone, E.,Saviano, M. (deposition date: 2003-01-28, release date: 2003-08-05, Last modification date: 2024-10-30)
Primary citation	Bartolucci, S.,De Simone, G.,Galdiero, S.,Improta, R.,Menchise, V.,Pedone, C.,Pedone, E.,Saviano, M. An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius J.Bacteriol., 185:4285-4289, 2003 Cited by PubMed Abstract: We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein. PubMed: 12837806 DOI: 10.1128/JB.185.14.4285-4289.2003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation