1NN0

Crystal structure of human thymidylate kinase with ddTMP and ADP

1NN0 の概要

• エントリーDOI: 10.2210/pdb1nn0/pdb
• 分子名称: Thymidylate kinase, MAGNESIUM ION, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: thymidylate kinase, p-loop, dideoxythymidine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24834.55

構造登録者

Ostermann, N.,Segura-Pena, D.,Meier, C.,Veit, T.,Monnerjahn, M.,Konrad, M.,Lavie, A. (登録日: 2003-01-12, 公開日: 2003-03-18, 最終更新日: 2024-02-14)

• 主引用文献: Ostermann, N.,Segura-Pena, D.,Meier, C.,Veit, T.,Monnerjahn, M.,Konrad, M.,Lavie, A.; Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds; Biochemistry, 42:2568-2577, 2003; PubMed: 12614151; DOI: 10.1021/bi027302t

実験手法

X-RAY DIFFRACTION (1.6 Å)