1NL4

Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor

1NL4 の概要

• エントリーDOI: 10.2210/pdb1nl4/pdb
• 分子名称: Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
• 機能のキーワード: transferase, prenyltransferase
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83340.93

構造登録者

Curtin, M.L.,Florjancic, A.S.,Cohen, J.,Gu, W.-J.,Frost, D.J.,Muchmore, S.W.,Sham, H.L. (登録日: 2003-01-06, 公開日: 2003-02-11, 最終更新日: 2024-02-14)

• 主引用文献: Curtin, M.L.,Florjancic, A.S.,Cohen, J.,Gu, W.-J.,Frost, D.J.,Muchmore, S.W.,Sham, H.L.; Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase; BIOORG.MED.CHEM.LETT., 13:1367-1371, 2003; PubMed: 12657284; DOI: 10.1016/S0960-894X(03)00096-9

実験手法

X-RAY DIFFRACTION (2.7 Å)