1NJU

Complex structure of HCMV Protease and a peptidomimetic inhibitor

1NJU の概要

• エントリーDOI: 10.2210/pdb1nju/pdb
• 関連するPDBエントリー: 1NJT 1NKK 1NKM
• 関連するBIRD辞書のPRD_ID: PRD_000283
• 分子名称: Assemblin, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
• 機能のキーワード: protease, peptidomimetic inhibitor, induced-fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human herpesvirus 5 (Human cytomegalovirus)
• 細胞内の位置: Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 115393.94

構造登録者

Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L. (登録日: 2003-01-02, 公開日: 2003-02-11, 最終更新日: 2024-03-13)

• 主引用文献: Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L.; Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease; Biochemistry, 42:885-891, 2003; PubMed: 12549906; DOI: 10.1021/bi027045s

実験手法

X-RAY DIFFRACTION (2.7 Å)