1ND5
Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and alpha-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design
Summary for 1ND5
Entry DOI | 10.2210/pdb1nd5/pdb |
Related | 1CVI 1ND6 2HPA |
Descriptor | prostatic acid phosphatase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | acid phosphatase, pap, prostate, phosphate, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 169944.22 |
Authors | Ortlund, E.,LaCount, M.W.,Lebioda, L. (deposition date: 2002-12-07, release date: 2002-12-20, Last modification date: 2023-08-16) |
Primary citation | Ortlund, E.,LaCount, M.W.,Lebioda, L. Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design Biochemistry, 42:383-389, 2003 Cited by PubMed: 12525165DOI: 10.1021/bi0265067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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