1NAL

THE THREE-DIMENSIONAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM ESCHERICHIA COLI

1NAL の概要

• エントリーDOI: 10.2210/pdb1nal/pdb
• 分子名称: N-ACETYLNEURAMINATE LYASE, SULFATE ION (3 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A6L4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131065.64

構造登録者

Izard, T.,Lawrence, M.C.,Malby, R.L.,Lilley, G.G.,Colman, P.M. (登録日: 1994-02-28, 公開日: 1995-09-15, 最終更新日: 2024-02-14)

主引用文献

Izard, T.,Lawrence, M.C.,Malby, R.L.,Lilley, G.G.,Colman, P.M.
The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli.
Structure, 2:361-369, 1994

PubMed Abstract: N-acetylneuraminate lyase catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetyl-D-mannosamine. The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. The reverse reaction can be exploited for the synthesis of sialic acid and some of its derivatives.

PubMed: 8081752
DOI: 10.1016/S0969-2126(00)00038-1

実験手法

X-RAY DIFFRACTION (2.2 Å)