1MX1
Crystal Structure of Human Liver Carboxylesterase in complex with tacrine
Summary for 1MX1
Entry DOI | 10.2210/pdb1mx1/pdb |
Related | 1MX5 1MX9 |
Descriptor | liver Carboxylesterase I, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | esterase, hydrolase, esterase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 367246.28 |
Authors | Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. (deposition date: 2002-10-01, release date: 2003-04-22, Last modification date: 2020-07-29) |
Primary citation | Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition CHEM.BIOL., 10:341-349, 2003 Cited by PubMed: 12725862DOI: 10.1016/S1074-5521(03)00071-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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