1MX1

Crystal Structure of Human Liver Carboxylesterase in complex with tacrine

1MX1 の概要

• エントリーDOI: 10.2210/pdb1mx1/pdb
• 関連するPDBエントリー: 1MX5 1MX9
• 分子名称: liver Carboxylesterase I, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: esterase, hydrolase, esterase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 367246.28

構造登録者

Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. (登録日: 2002-10-01, 公開日: 2003-04-22, 最終更新日: 2020-07-29)

• 主引用文献: Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R.; Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition; CHEM.BIOL., 10:341-349, 2003; PubMed: 12725862; DOI: 10.1016/S1074-5521(03)00071-1

実験手法

X-RAY DIFFRACTION (2.4 Å)