1MV0

NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

Summary for 1MV0

Related1MUZ 1MV3
DescriptorMyc proto-oncogene protein, Myc box-dependent-interacting protein 1 (2 entities in total)
Functional Keywordstumor suppressor/oncoprotein, endocytosis/exocytosis, transcription complex, endocytosis-exocytosis, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm P01106
Isoform BIN1: Nucleus. Isoform IIA: Cytoplasm O00499
Total number of polymer chains2
Total molecular weight10836.2
Authors
Pineda-Lucena, A.,Arrowsmith, C.H. (deposition date: 2002-09-24, release date: 2003-09-30, Last modification date: 2011-07-13)
Primary citation
Pineda-Lucena, A.,Ho, C.S.,Mao, D.Y.,Sheng, Y.,Laister, R.C.,Muhandiram, R.,Lu, Y.,Seet, B.T.,Katz, S.,Szyperski, T.,Penn, L.Z.,Arrowsmith, C.H.
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
J.Mol.Biol., 351:182-194, 2005
PubMed: 15992821 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2005.05.046
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers48 4.1% 31.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
171916
PDB entries from 2020-12-02