1MV0
NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC
Summary for 1MV0
Entry DOI | 10.2210/pdb1mv0/pdb |
Related | 1MUZ 1MV3 |
Descriptor | Myc proto-oncogene protein, Myc box-dependent-interacting protein 1 (2 entities in total) |
Functional Keywords | tumor suppressor/oncoprotein, endocytosis/exocytosis, transcription complex, endocytosis-exocytosis, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus, nucleoplasm: P01106 Isoform BIN1: Nucleus. Isoform IIA: Cytoplasm: O00499 |
Total number of polymer chains | 2 |
Total formula weight | 10836.20 |
Authors | Pineda-Lucena, A.,Arrowsmith, C.H. (deposition date: 2002-09-24, release date: 2003-09-30, Last modification date: 2024-05-22) |
Primary citation | Pineda-Lucena, A.,Ho, C.S.,Mao, D.Y.,Sheng, Y.,Laister, R.C.,Muhandiram, R.,Lu, Y.,Seet, B.T.,Katz, S.,Szyperski, T.,Penn, L.Z.,Arrowsmith, C.H. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J.Mol.Biol., 351:182-194, 2005 Cited by PubMed: 15992821DOI: 10.1016/j.jmb.2005.05.046 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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