1MTR
HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR
Summary for 1MTR
Entry DOI | 10.2210/pdb1mtr/pdb |
Related PRD ID | PRD_000269 |
Descriptor | HIV-1 PROTEASE, SULFATE ION, [1-BENZYL-3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YLAMINO)-2-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER, ... (4 entities in total) |
Functional Keywords | aspartyl proteinase, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22416.32 |
Authors | Wickramasinghe, W.,Begun, J.,Martin, J.L. (deposition date: 1996-02-15, release date: 1996-08-01, Last modification date: 2023-08-09) |
Primary citation | March, D.R.,Abbenante, G.,Bergman, D.A.,Brinkworth, R.I.,Wickramasinghe, W.,Begun, J.,Martin, J.L.,Fairlie, D.P. Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode. J.Am.Chem.Soc., 118:3375-3379, 1996 Cited by |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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