1MTB

Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy

1MTB の概要

関連するPDBエントリー1F7A 1HXB 1MT7 1MT8 1MT9
分子名称PROTEASE RETROPEPSIN, quinoline-2-carboxylic acid, ASPARAGINE, ... (7 entities in total)
機能のキーワードhiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Human immunodeficiency virus 1
詳細
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
ポリマー鎖数2
分子量合計22342.36
構造登録者
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2002-09-20, 公開日: 2003-01-07, 最終更新日: 2017-10-11)
主引用文献
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.
Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77:1305-1315, 2003
PubMed: 12502847 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.77.2.1306-1315.2003
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.5 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers1004.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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