1MTB
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10799.7 | 2 | UniProt (P03369) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | A | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide | non-polymer | 670.8 | 1 | BIRD (PRD_000454) Chemie (ROC) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Asp 81 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21599.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 670.8 | |
| All* | Total formula weight | 22270.3 |
