1MTB
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10799.7 | 2 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide | non-polymer | 670.8 | 1 | BIRD (PRD_000454) Chemie (ROC) PubChem (441243) PubChem (44341147) PubChem (454468) PubChem (454469) PubChem (454470) PubChem (466470) PubChem (44302795) PubChem (59793479) PubChem (59871017) PubChem (59923166) PubChem (66577040) PubChem (67631661) PubChem (59964683) PubChem (67631659) PubChem (5472919) PubChem (3000788) PubChem (86575993) PubChem (60787) PubChem (60935) PubChem (6604589) PubChem (90772039) PubChem (11422480) PubChem (3579812) PubChem (118718788) PubChem (101609863) PubChem (126968593) PubChem (129626579) PubChem (134694388) PubChem (124587484) PubChem (140571999) PubChem (129626581) PubChem (131839596) PubChem (15107606) PubChem (135285682) PubChem (146347457) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Asp 81 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21599.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 670.8 | |
| All* | Total formula weight | 22270.3 |
