1MTB
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10799.7 | 2 | UniProt (P03369) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | A | quinoline-2-carboxylic acid | non-polymer | 173.2 | 1 | Chemie (QNC) | |||
| 3 | A | ASPARAGINE | non-polymer | 132.1 | 1 | Chemie (ASN) | |||
| 4 | A | (2S)-2-amino-3-phenylpropane-1,1-diol | non-polymer | 167.2 | 1 | Chemie (HPH) | |||
| 5 | B | 2-METHYL-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID | non-polymer | 197.3 | 1 | Chemie (DIQ) | |||
| 6 | B | TERTIARY-BUTYLAMINE | non-polymer | 73.1 | 1 | Chemie (NTB) | |||
| 7 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Asp 81 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21599.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 742.9 | |
| All* | Total formula weight | 22342.4 |
