1MT8

Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy

1MT8 の概要

関連するPDBエントリー1KJ4 1MTR 1MT7 1MT9 1MTB
分子名称PROTEASE RETROPEPSIN, Capsid-p2 substrate peptide of HIV-1 Gag polyprotein, ACETATE ION, ... (4 entities in total)
機能のキーワードmatrix, capsid, gag cleavage, drug resistance, substrate recognition, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
由来する生物種Human immunodeficiency virus 1
詳細
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
ポリマー鎖数3
分子量合計22799.88
構造登録者
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2002-09-20, 公開日: 2003-01-07, 最終更新日: 2017-10-11)
主引用文献
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.
Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77:1305-1315, 2003
PubMed: 12502847 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.77.2.1306-1315.2003
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.15 Å)
?

構造検証レポート

ClashscoreRamachandran outliersSidechain outliers1302.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード