1MT8

Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy

1MT8 の概要

• エントリーDOI: 10.2210/pdb1mt8/pdb
• 関連するPDBエントリー: 1KJ4 1MT7 1MT9 1MTB 1MTR
• 分子名称: PROTEASE RETROPEPSIN, Capsid-p2 substrate peptide of HIV-1 Gag polyprotein, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: matrix, capsid, gag cleavage, drug resistance, substrate recognition, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22799.88

構造登録者

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2002-09-20, 公開日: 2003-01-07, 最終更新日: 2024-02-14)

• 主引用文献: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy; J.Virol., 77:1305-1315, 2003; PubMed: 12502847; DOI: 10.1128/JVI.77.2.1306-1315.2003

実験手法

X-RAY DIFFRACTION (2.15 Å)