1MT6

Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy

1MT6 の概要

• エントリーDOI: 10.2210/pdb1mt6/pdb
• 関連するPDBエントリー: 1MUF
• 分子名称: SET9, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• 機能のキーワード: set domain, histone lysine methyltransferase, adohcy, knot, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8WTS6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31534.82

構造登録者

Jacobs, S.A.,Harp, J.M.,Devarakonda, S.,Kim, Y.,Rastinejad, F.,Khorasanizadeh, S. (登録日: 2002-09-20, 公開日: 2002-11-06, 最終更新日: 2024-02-14)

主引用文献

Jacobs, S.A.,Harp, J.M.,Devarakonda, S.,Kim, Y.,Rastinejad, F.,Khorasanizadeh, S.
The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9:833-838, 2002

PubMed Abstract: The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.

PubMed: 12389038

実験手法

X-RAY DIFFRACTION (2.2 Å)