1MRS

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE

1MRS の概要

• エントリーDOI: 10.2210/pdb1mrs/pdb
• 関連するPDBエントリー: 1G3U 1MRN
• 分子名称: THYMIDYLATE KINASE, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: transferase (atp:tmp phosphotransferase), kinase, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23217.16

構造登録者

Haouz, A.,Vanheusden, V.,Munier-Lehmann, H.,Froeyen, M.,Herdewijn, P.,Van Calenbergh, S.,Delarue, M. (登録日: 2002-09-18, 公開日: 2003-01-07, 最終更新日: 2024-02-14)

• 主引用文献: Haouz, A.,Vanheusden, V.,Munier-Lehmann, H.,Froeyen, M.; Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.; J.Biol.Chem., 278:4963-4971, 2003; PubMed: 12454011; DOI: 10.1074/jbc.M209630200

実験手法

X-RAY DIFFRACTION (2 Å)