1MRQ

Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone

Summary for 1MRQ

Entry DOI	10.2210/pdb1mrq/pdb
Descriptor	Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total)
Functional Keywords	20alpha-hsd, hydroxysteroid dehydrogenase, progesterone, ternary complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q04828
Total number of polymer chains	1
Total formula weight	37972.27
Authors	Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. (deposition date: 2002-09-18, release date: 2003-09-30, Last modification date: 2024-02-14)
Primary citation	Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J.Mol.Biol., 331:593-604, 2003 Cited by PubMed: 12899831 DOI: 10.1016/S0022-2836(03)00762-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation