1MRQ
Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldo-keto reductase family 1 member C1 | polymer | 323 | 36836.3 | 1 | UniProt (Q04828) Pfam (PF00248) | Homo sapiens (human) | 20alpha-hydroxysteroid dehydrogenase, Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase, High-affinity hepatic bile acid-binding protein, HBAB, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 2, DD2 |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 3 | C (A) | PROGESTERONE | non-polymer | 314.5 | 1 | Chemie (STR) PubChem (4920) PubChem (5994) PubChem (92940) PubChem (638017) PubChem (657254) PubChem (1274466) PubChem (5320716) PubChem (6576615) PubChem (7048588) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (7092666) PubChem (9948776) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (23615931) PubChem (71200542) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (1201516) PubChem (54269928) PubChem (6603959) PubChem (7004693) PubChem (57526392) PubChem (11869416) PubChem (144033743) PubChem (12303982) PubChem (12303979) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (170068371) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (117072378) PubChem (118670641) PubChem (123410055) PubChem (129010392) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 4 | D (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 5 | E (A) | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A: 2 - 323 (UniProt: Q04828)
| PDB | External Database | Details |
|---|---|---|
| Gln 1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36836.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1136.0 | |
| All* | Total formula weight | 37972.3 |
