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1MRN

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)

Summary for 1MRN
Entry DOI10.2210/pdb1mrn/pdb
Related1G3U 1MRS
DescriptorThymidylate Kinase, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordstransferase (atp:tmp phosphotransferase), kinase, transferase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total formula weight23770.31
Authors
Haouz, A.,Vanheusden, V.,Munier-Lehmann, H.,Froeyen, M.,Herdewijn, P.,Van Calenbergh, S.,Delarue, M. (deposition date: 2002-09-18, release date: 2003-01-07, Last modification date: 2024-02-14)
Primary citationHaouz, A.,Vanheusden, V.,Munier-Lehmann, H.,Froeyen, M.,Herdewijn, P.,Van Calenbergh, S.,Delarue, M.
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278:4963-4971, 2003
Cited by
PubMed: 12454011
DOI: 10.1074/jbc.M209630200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

221051

數據於2024-06-12公開中

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