1MQ5
Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa
Summary for 1MQ5
Entry DOI | 10.2210/pdb1mq5/pdb |
Related | 1EZQ 1F0R 1F0S 1FJS 1mq6 1QL7 1QL9 |
Descriptor | COAGULATION FACTOR X HEAVY CHAIN, COAGULATION FACTOR X LIGHT CHAIN, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | protein inhibitor complex, coagulation cofactor, protease, blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32660.37 |
Authors | Adler, M.,Whitlow, M. (deposition date: 2002-09-13, release date: 2003-01-28, Last modification date: 2017-10-11) |
Primary citation | Adler, M.,Kochanny, M.J.,Bin, Y.,Rumennik, G.,Light, D.L.,Biancalana, S.,Whitlow, M. Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa Biochemistry, 41:15514-15523, 2002 Cited by PubMed: 12501180DOI: 10.1021/bi0264061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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