1MOE

The three-dimensional structure of an engineered scFv T84.66 dimer or diabody in VL to VH linkage.

Summary for 1MOE

• Entry DOI: 10.2210/pdb1moe/pdb
• Descriptor: anti-CEA mAb T84.66, SULFATE ION (3 entities in total)
• Functional Keywords: anti carcinoembryonic antigen, t84.66, diabody, dimer, scfv, variable domain, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 51919.43

Authors

Carmichael, J.A.,Power, B.E.,Garrett, T.P.J.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J. (deposition date: 2002-09-09, release date: 2003-03-18, Last modification date: 2023-10-25)

• Primary citation: Carmichael, J.A.,Power, B.E.,Garrett, T.P.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J.; The Crystal Structure of an Anti-CEA scFv Diabody Assembled from T84.66 scFvs in VL-to-VH Orientation: Implications for Diabody Flexibility; J.Mol.Biol., 326:341-351, 2003; PubMed: 12559905; DOI: 10.1016/S0022-2836(02)01428-6

Experimental method

X-RAY DIFFRACTION (2.6 Å)