1MMJ

Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706

Summary for 1MMJ

Entry DOI	10.2210/pdb1mmj/pdb
Descriptor	elastase 1, SULFATE ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	chymotrypsin family, hydrolase
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26635.72
Authors	Kinoshita, T. (deposition date: 2002-09-04, release date: 2002-12-23, Last modification date: 2024-11-20)
Primary citation	Kinoshita, T.,Nakanishi, I.,Sato, A.,Tada, T. True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor Bioorg.Med.Chem.Lett., 13:21-24, 2003 Cited by PubMed Abstract: The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors. PubMed: 12467609 DOI: 10.1016/S0960-894X(02)00852-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation