1MMJ

Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706

Functional Information from GO Data

Chain	GOid	namespace	contents
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0006508	biological_process	proteolysis
N	0006954	biological_process	inflammatory response
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0016787	molecular_function	hydrolase activity
N	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 N 1242

Chain	Residue
N	GLY118
N	ARG225
N	SER227
N	ALA228
N	HOH1276
N	HOH1284
N	HOH1404
N	HOH1439

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA N 250

Chain	Residue
N	ASN61
N	ASN63
N	GLN64
N	ASP66
N	GLU69
N	HOH1281
N	GLU59

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FR1 N 241

Chain	Residue
N	ARG21
N	CYS30
N	HIS45
N	GLU50
N	LEU51
N	THR52
N	ALA89
N	TRP164
N	THR167
N	CYS184
N	GLN185
N	GLY186
N	ASP187
N	SER188
N	THR206
N	SER207
N	PHE208
N	VAL209
N	SER210
N	ARG211
N	HOH1327
N	HOH1398
N	HOH1454
N	HOH1494
N	HOH1509

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC

Chain	Residue	Details
N	MET41-CYS46

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH

Chain	Residue	Details
N	SER182-HIS193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	237
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"4578945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7656008","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ELA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	HIS45
N	ASP93

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	GLY189
N	SER188

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	GLY186
N	SER188

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	HIS45
N	ASP93
N	SER188

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	GLY189
N	HIS45
N	ASP93
N	SER188

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	GLY186
N	HIS45
N	ASP93
N	SER188

---

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	SER207
N	GLY186
N	HIS45
N	ASP93
N	SER188

---