1MK1

Structure of the MT-ADPRase in complex with ADPR, a Nudix enzyme

1MK1 の概要

• エントリーDOI: 10.2210/pdb1mk1/pdb
• 関連するPDBエントリー: 1g0s 1g9q 1ga7
• 分子名称: ADPR pyrophosphatase, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• 機能のキーワード: nudix hydrolase, adpr pyrophosphatase, adprase, adenosine diphospho-ribose, mycobacterium tuberculosis, rv1700, hydrolase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23480.16

構造登録者

Kang, L.-W.,Gabelli, S.B.,Bianchet, M.A.,Cunningham, J.E.,O'Handley, S.F.,Amzel, L.M. (登録日: 2002-08-28, 公開日: 2003-08-05, 最終更新日: 2024-02-14)

主引用文献

Kang, L.-W.,Gabelli, S.B.,Cunningham, J.E.,O'Handley, S.F.,Amzel, L.M.
Structure and mechanism of MT-ADPRase, a Nudix hydrolase from Mycobacterium tuberculosis
Structure, 11:1015-1023, 2003

PubMed Abstract: Nudix hydrolases are a family of proteins that contain the characteristic sequence GX(5)EX(7)REUXEEXG(I/L/V), the Nudix box. They catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives such as ADP-ribose, Ap(n)A (3 PubMed: 12906832
DOI: 10.1016/S0969-2126(03)00154-0

実験手法

X-RAY DIFFRACTION (2 Å)