1MBT

OXIDOREDUCTASE

1MBT の概要

• エントリーDOI: 10.2210/pdb1mbt/pdb
• 分子名称: URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: flavoenzyme, oxidoreductase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm (Probable): P08373
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38773.52

構造登録者

Benson, T.E.,Walsh, C.T.,Hogle, J.M. (登録日: 1995-11-28, 公開日: 1996-10-14, 最終更新日: 2024-02-14)

主引用文献

Benson, T.E.,Walsh, C.T.,Hogle, J.M.
The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls.
Structure, 4:47-54, 1996

PubMed Abstract: The repeating disaccharide and pentapeptide units of the bacterial peptidoglycan layer are connected by a lactyl ether bridge biosynthesized from UDP-N-acetylglucosamine and phosphoenolpyruvate in sequential enol ether transfer and reduction steps catalyzed by MurA and MurB respectively. Knowledge of the structure and mechanism of the MurB enzyme will permit analysis of this unusual enol ether reduction reaction and may facilitate the design of inhibitors as candidate next-generation antimicrobial agents.

PubMed: 8805513
DOI: 10.1016/S0969-2126(96)00008-1

実験手法

X-RAY DIFFRACTION (3 Å)