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1MBF

MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1

Summary for 1MBF
Entry DOI10.2210/pdb1mbf/pdb
DescriptorMYB PROTO-ONCOGENE PROTEIN (1 entity in total)
Functional Keywordsprotooncogene product, dna binding protein
Biological sourceMus musculus (house mouse)
Cellular locationNucleus: P06876
Total number of polymer chains1
Total formula weight6317.11
Authors
Ogata, K.,Morikawa, S.,Nakamura, H.,Hojo, H.,Yoshimura, S.,Zhang, R.,Aimoto, S.,Ametani, Y.,Hirata, Z.,Sarai, A.,Ishii, S.,Nishimura, Y. (deposition date: 1995-05-19, release date: 1995-07-31, Last modification date: 2024-10-16)
Primary citationOgata, K.,Morikawa, S.,Nakamura, H.,Hojo, H.,Yoshimura, S.,Zhang, R.,Aimoto, S.,Ametani, Y.,Hirata, Z.,Sarai, A.,Ishii, S.,Nishimura, Y.
Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.
Nat.Struct.Biol., 2:309-320, 1995
Cited by
PubMed Abstract: The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.
PubMed: 7796266
DOI: 10.1038/nsb0495-309
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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