1MAR
REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
Summary for 1MAR
Entry DOI | 10.2210/pdb1mar/pdb |
Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID (3 entities in total) |
Functional Keywords | oxidoreductase(nadp) |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36929.93 |
Authors | Wilson, D.K.,Quiocho, F.A. (deposition date: 1993-07-20, release date: 1995-07-20, Last modification date: 2024-02-14) |
Primary citation | Wilson, D.K.,Tarle, I.,Petrash, J.M.,Quiocho, F.A. Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc.Natl.Acad.Sci.USA, 90:9847-9851, 1993 Cited by PubMed: 8234324DOI: 10.1073/pnas.90.21.9847 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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