1M7I

CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A PENTASACCHARIDE

Summary for 1M7I

• Entry DOI: 10.2210/pdb1m7i/pdb
• Related: 1M71 1M7D 1MCP
• Descriptor: light chain of the monoclonal antibody Fab SYA/J6, heavy chain of the monoclonal antibody Fab SYA/J6, alpha-L-rhamnopyranose-(1-2)-alpha-L-rhamnopyranose-(1-3)-alpha-L-rhamnopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-methyl 6-deoxy-alpha-L-rhamnopyranoside, ... (4 entities in total)
• Functional Keywords: fab-carbohydrate interactions; shigella o-antigen; and anti-carbohydrate antibody, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48084.51

Authors

Vyas, N.K.,Vyas, M.N.,Chervenak, M.C.,Johnson, M.A.,Pinto, B.M.,Bundle, D.R.,Quiocho, F.A. (deposition date: 2002-07-19, release date: 2003-07-22, Last modification date: 2020-07-29)

• Primary citation: Vyas, N.K.,Vyas, M.N.,Chervenak, M.C.,Johnson, M.A.,Pinto, B.M.,Bundle, D.R.,Quiocho, F.A.; Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab Specific for Shigella flexneri Y Lipopolysaccharide: X-ray Structures and Thermodynamics; Biochemistry, 41:13575-13586, 2002; PubMed: 12427018; DOI: 10.1021/bi0261387

Experimental method

X-RAY DIFFRACTION (2.5 Å)