1M6F
Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove
Summary for 1M6F
Entry DOI | 10.2210/pdb1m6f/pdb |
Descriptor | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ... (4 entities in total) |
Functional Keywords | nucleic acids, minor groove binder, double helix, dna-drug complex, dna |
Total number of polymer chains | 2 |
Total formula weight | 7703.51 |
Authors | Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D. (deposition date: 2002-07-16, release date: 2002-11-15, Last modification date: 2024-04-03) |
Primary citation | Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D. Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove J.Am.Chem.Soc., 124:13680-13681, 2002 Cited by PubMed: 12431090DOI: 10.1021/ja027953c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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