1M6B

Structure of the HER3 (ERBB3) Extracellular Domain

1M6B の概要

• エントリーDOI: 10.2210/pdb1m6b/pdb
• 分子名称: Receptor protein-tyrosine kinase erbB-3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: tyrosine kinase; cell surface receptor; immunity, signaling protein, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 140573.66

構造登録者

Leahy, D.J.,Cho, H.-S. (登録日: 2002-07-15, 公開日: 2002-08-02, 最終更新日: 2024-10-30)

主引用文献

Cho, H.S.,Leahy, D.J.
Structure of the extracellular region of HER3 reveals an interdomain tether.
Science, 297:1330-1333, 2002

PubMed Abstract: We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.

PubMed: 12154198
DOI: 10.1126/science.1074611

実験手法

X-RAY DIFFRACTION (2.6 Å)