1LYP
THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES
Summary for 1LYP
| Entry DOI | 10.2210/pdb1lyp/pdb |
| Descriptor | CAP18 (1 entity in total) |
| Functional Keywords | lipopolysaccharide-binding protein |
| Biological source | Oryctolagus cuniculus (rabbit) |
| Cellular location | Secreted: P25230 |
| Total number of polymer chains | 1 |
| Total formula weight | 3813.82 |
| Authors | Chen, C.,Huang, T.-H. (deposition date: 1995-01-12, release date: 1995-03-31, Last modification date: 2024-05-22) |
| Primary citation | Chen, C.,Brock, R.,Luh, F.,Chou, P.J.,Larrick, J.W.,Huang, R.F.,Huang, T.H. The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett., 370:46-52, 1995 Cited by PubMed Abstract: We have employed the circular dichroism (CD) technique to characterize the solution structure of CAP18(106-137), a lipopolysaccharide (LPS) binding, antimicrobial protein, and its interaction with lipid A. Our results revealed that CAP18(106-137) may exist in at least three lipid A concentration-dependent, primarily helix conformations. The 'model' structure of CAP18(106-137) in 30% (v/v) TFE, determined by nuclear magnetic resonance (NMR) technique, was found to be a complete and very rigid helix. In this conformation, the cationic and hydrophobic groups of CAP18(106-137) are separated into patches and stripes in such a way that it can favorably interact with lipid A through either coulombic interaction with the diphosphoryl groups or hydrophobic interaction with the fatty acyl chains. PubMed: 7649303DOI: 10.1016/0014-5793(95)00792-8 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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