1LQD

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.

1LQD の概要

• エントリーDOI: 10.2210/pdb1lqd/pdb
• 関連するPDBエントリー: 1LPG 1LPK 1LPZ 1LQE
• 分子名称: Blood coagulation factor Xa, CALCIUM ION, 1-(3-CARBAMIMIDOYL-BENZYL)-4-METHYL-1H-INDOLE-2-CARBOXYLIC ACID 3,5-DIMETHYL-BENZYLAMIDE, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, blood coagulation factor, serine proteinase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44226.00

構造登録者

Schreuder, H.A.,Loenze, P.,Brachvogel, V.,Liesum, A. (登録日: 2002-05-10, 公開日: 2003-05-10, 最終更新日: 2011-07-13)

• 主引用文献: Matter, H.,Defossa, E.,Heinelt, U.,Blohm, P.M.,Schneider, D.,Mueller, A.,Herok, S.,Schreuder, H.A.,Liesum, A.,Brachvogel, V.,Loenze, P.,Walser, A.,Al-Obeidi, F.,Wildgoose, P.; Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa; J.Med.Chem., 45:2749-2769, 2002; PubMed: 12061878; DOI: 10.1021/jm0111346

実験手法

X-RAY DIFFRACTION (2.7 Å)