1LMK

THE STRUCTURE OF A BIVALENT DIABODY

1LMK の概要

• エントリーDOI: 10.2210/pdb1lmk/pdb
• 分子名称: ANTI-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY (2 entities in total)
• 機能のキーワード: immunoglobulin, diabody, single-chain fv, scfv
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 104312.48

構造登録者

Williams, R.L. (登録日: 1994-08-29, 公開日: 1995-03-31, 最終更新日: 2024-10-30)

主引用文献

Perisic, O.,Webb, P.A.,Holliger, P.,Winter, G.,Williams, R.L.
Crystal structure of a diabody, a bivalent antibody fragment.
Structure, 2:1217-1226, 1994

PubMed Abstract: Diabodies are dimeric antibody fragments. In each polypeptide, a heavy-chain variable domain (VH) is linked to a light-chain variable domain (VL) but unlike single-chain Fv fragments, each antigen-binding site is formed by pairing of one VH and one VL domain from the two different polypeptides. Diabodies thus have two antigen-binding sites, and can be bispecific. Direct structural evidence is lacking for the connections and dimeric interactions between the two polypeptides of the diabody.

PubMed: 7704531
DOI: 10.1016/S0969-2126(94)00123-5

実験手法

X-RAY DIFFRACTION (2.6 Å)