1LKY

Structure of the wild-type TEL-SAM polymer

1LKY の概要

• エントリーDOI: 10.2210/pdb1lky/pdb
• 分子名称: TRANSCRIPTION FACTOR ETV6, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: leukemia, tyrosine kinase, transcriptional repression, drug design, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P41212 P41212
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 56698.08

構造登録者

Tran, H.H.,Kim, C.A.,Faham, S.,Bowie, J.U. (登録日: 2002-04-26, 公開日: 2002-06-12, 最終更新日: 2023-08-16)

主引用文献

Tran, H.H.,Kim, C.A.
Native interface of the SAM domain polymer of TEL.
BMC STRUCT.BIOL., 2:5-5, 2002

PubMed Abstract: TEL is a transcriptional repressor containing a SAM domain that forms a helical polymer. In a number of hematologic malignancies, chromosomal translocations lead to aberrant fusions of TEL-SAM to a variety of other proteins, including many tyrosine kinases. TEL-SAM polymerization results in constitutive activation of the tyrosine kinase domains to which it becomes fused, leading to cell transformation. Thus, inhibitors of TEL-SAM self-association could abrogate transformation in these cells. In previous work, we determined the structure of a mutant TEL-SAM polymer bearing a Val to Glu substitution in center of the subunit interface. It remained unclear how much the mutation affected the architecture of the polymer, however.

PubMed: 12193272
DOI: 10.1186/1472-6807-2-5

実験手法

X-RAY DIFFRACTION (2.3 Å)