1LHC

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROARG-OH

Summary for 1LHC
DescriptorALPHA-THROMBIN, HIRUDIN, AC-(D)PHE-PRO-BOROARG-OH, ... (5 entities in total)
Functional Keywordsblood coagulation, plasma, calcium-binding, glycoprotein, duplication, vitamin k, zymogen, gamma-carboxyglutamic acid, acute phase, liver, hydrolase, serine protease, kringle, disease mutation, complex (serine protease-inhibitor), complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
Biological sourceHirudo medicinalis (medicinal leech)
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Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains3
Total formula weight35805.60
Authors
Weber, P.C.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Chang, C.H.,Kettner, C.A. (deposition date: 1994-12-27, release date: 1996-11-08, Last modification date: 2011-07-13)
Primary citationChang, C.W.,Kettner, C.A.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Weber, P.C.
Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
Biochemistry, 34:3750-3757, 1995
PubMed: 7893672
DOI: 110.1021/bi00011a033
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation
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PDB entries from 2021-06-23