1LF3

CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR EH58

Summary for 1LF3

Entry DOI	10.2210/pdb1lf3/pdb
Related	1JGF 1LF2 1LF4 1LFE 1SME
Descriptor	plasmepsin 2, N-(1-BENZYL-3-{[3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONYL]-[2-(HEXAHYDRO-BENZO[1,3]DIOXOL-5-YL)-ETHYL]-AMINO}-2-HYDROXY-PROPYL)-4-BENZYLOXY-3,5-DIMETHOXY-BENZAMIDE (3 entities in total)
Functional Keywords	plasmepsin, plasmodium falciparum, aspartic protease, hydrolase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Cellular location	Vacuole: P46925
Total number of polymer chains	1
Total formula weight	37929.85
Authors	Asojo, O.A.,Gulnik, S.V.,Afonina, E.,Yu, B.,Ellman, J.A.,Haque, T.S.,Silva, A.M. (deposition date: 2002-04-10, release date: 2002-10-10, Last modification date: 2023-08-16)
Primary citation	Asojo, O.A.,Gulnik, S.V.,Afonina, E.,Yu, B.,Ellman, J.A.,Haque, T.S.,Silva, A.M. Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum. J.Mol.Biol., 327:173-181, 2003 Cited by PubMed: 12614616 DOI: 10.1016/S0022-2836(03)00036-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation