1LEJ

NMR Structure of a 1:1 Complex of Polyamide (Im-Py-Beta-Im-Beta-Im-Py-Beta-Dp) with the Tridecamer DNA Duplex 5'-CCAAAGAGAAGCG-3'

Summary for 1LEJ

• Entry DOI: 10.2210/pdb1lej/pdb
• NMR Information: BMRB: 5370
• Descriptor: 5'-D(*CP*CP*AP*AP*AP*GP*AP*GP*AP*AP*GP*CP*G)-3', 5'-D(*CP*GP*CP*TP*TP*CP*TP*CP*TP*TP*TP*GP*G)-3', IMIDAZOLE-PYRROLE-BETA ALANINE-IMIDAZOLE-BETA ALANINE-IMIDAZOLE-PYRROLE-BETA ALANINE-DIMETHYLAMINO PROPYLAMIDE (3 entities in total)
• Functional Keywords: polyamide, purine tract, beta alanine, minor groove, dna
• Total number of polymer chains: 2
• Total formula weight: 8858.19

Authors

Urbach, A.R.,Love, J.J.,Ross, S.A.,Dervan, P.B. (deposition date: 2002-04-09, release date: 2002-05-08, Last modification date: 2022-02-23)

• Primary citation: Urbach, A.R.,Love, J.J.,Ross, S.A.,Dervan, P.B.; Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif.; J.Mol.Biol., 320:55-71, 2002; PubMed: 12079334; DOI: 10.1016/S0022-2836(02)00430-8

Experimental method

SOLUTION NMR