1L8S

CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + LPC-ether + ACETATE + PHOSPHATE IONS)

Summary for 1L8S

Entry DOI	10.2210/pdb1l8s/pdb
Related	1FX9 1FXF
Descriptor	PHOSPHOLIPASE A2, MAJOR ISOENZYME, CALCIUM ION, SODIUM ION, ... (7 entities in total)
Functional Keywords	hydrolase, enzyme, carboxylic ester hydrolase, dimer, paf hydrolysis products binding, phosphate binding
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00592
Total number of polymer chains	2
Total formula weight	29167.18
Authors	Pan, Y.H.,Bahnson, B.J. (deposition date: 2002-03-21, release date: 2002-12-25, Last modification date: 2018-01-31)
Primary citation	Pan, Y.H.,Yu, B.-Z.,Berg, O.G.,Jain, M.K.,Bahnson, B.J. Crystal structure of phospholipase A2 Complex with the Hydrolysis Products of Platelet Activating Factor: Equilibrium Binding of Fatty Acid and Lysophospholipid-ether at the Active Site may be Mutually Exclusive Biochemistry, 41:14790-14800, 2002 Cited by PubMed: 12475227 DOI: 10.1021/bi026922r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation