1L2J
Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
Summary for 1L2J
Entry DOI | 10.2210/pdb1l2j/pdb |
Related | 1L2I 1QKM |
Descriptor | ESTROGEN RECEPTOR BETA, (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, estrogen, antagonist, transcription receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q92731 |
Total number of polymer chains | 2 |
Total formula weight | 61783.09 |
Authors | Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L. (deposition date: 2002-02-21, release date: 2002-05-01, Last modification date: 2023-08-16) |
Primary citation | Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat.Struct.Biol., 9:359-364, 2002 Cited by PubMed: 11953755PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
Download full validation report