1KZY

Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53

1KZY の概要

• エントリーDOI: 10.2210/pdb1kzy/pdb
• 分子名称: CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (4 entities in total)
• 機能のキーワード: tandem-brct and linker complexed with non-brct protein, three-helix bundle, parallel beta sheet, dna binding protein, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637; Nucleus: Q12888
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102558.84

構造登録者

Joo, W.S.,Jeffrey, P.D.,Cantor, S.B.,Finnin, M.S.,Livingston, D.M.,Pavletich, N.P. (登録日: 2002-02-08, 公開日: 2002-03-20, 最終更新日: 2011-07-13)

• 主引用文献: Joo, W.S.,Jeffrey, P.D.,Cantor, S.B.,Finnin, M.S.,Livingston, D.M.,Pavletich, N.P.; Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.; Genes Dev., 16:583-593, 2002; PubMed: 11877378; DOI: 10.1101/gad.959202

実験手法

X-RAY DIFFRACTION (2.5 Å)