1KYN

Cathepsin-G

Summary for 1KYN

• Entry DOI: 10.2210/pdb1kyn/pdb
• Descriptor: cathepsin G, (2-NAPHTHALEN-2-YL-1-NAPHTHALEN-1-YL-2-OXO-ETHYL)-PHOSPHONIC ACID (2 entities in total)
• Functional Keywords: serine protease, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cell surface: P08311
• Total number of polymer chains: 2
• Total formula weight: 54356.26

Authors

Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond Jr., H.R.,Corcoran, T.W.,De Garavilla, L.,Kauffman, J.A.,Recacha, R.,Chattopadhyay, D.,Andrade-Gordon, P.,Maryanoff, B.E. (deposition date: 2002-02-05, release date: 2002-05-01, Last modification date: 2011-07-13)

• Primary citation: Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond Jr., H.R.,Corcoran, T.W.,de Garavilla, L.,Kauffman, J.A.,Recacha, R.,Chattopadhyay, D.,Andrade-Gordon, P.,Maryanoff, B.E.; Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design.; J.Am.Chem.Soc., 124:3810-3811, 2002; PubMed: 11942800; DOI: 10.1021/ja017506h

Experimental method

X-RAY DIFFRACTION (3.5 Å)