1KVO

HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE

Summary for 1KVO

Entry DOI	10.2210/pdb1kvo/pdb
Descriptor	HUMAN PHOSPHOLIPASE A2, CALCIUM ION, 4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase, lipid degradation, membrane, calcium
Biological source	Homo sapiens (human)
Cellular location	Membrane; Peripheral membrane protein: P14555
Total number of polymer chains	6
Total formula weight	87173.18
Authors	Cha, S.-S.,Abdel-Meguid, S.S.,Oh, B.-H. (deposition date: 1996-07-29, release date: 1997-07-07, Last modification date: 2024-10-23)
Primary citation	Cha, S.S.,Lee, D.,Adams, J.,Kurdyla, J.T.,Jones, C.S.,Marshall, L.A.,Bolognese, B.,Abdel-Meguid, S.S.,Oh, B.H. High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX). J.Med.Chem., 39:3878-3881, 1996 Cited by PubMed: 8831753 DOI: 10.1021/jm960502g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation