1KVO

HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE

1KVO の概要

• エントリーDOI: 10.2210/pdb1kvo/pdb
• 分子名称: HUMAN PHOSPHOLIPASE A2, CALCIUM ION, 4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: hydrolase, lipid degradation, membrane, calcium
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Peripheral membrane protein: P14555
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 87173.18

構造登録者

Cha, S.-S.,Abdel-Meguid, S.S.,Oh, B.-H. (登録日: 1996-07-29, 公開日: 1997-07-07, 最終更新日: 2011-07-13)

• 主引用文献: Cha, S.S.,Lee, D.,Adams, J.,Kurdyla, J.T.,Jones, C.S.,Marshall, L.A.,Bolognese, B.,Abdel-Meguid, S.S.,Oh, B.H.; High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX).; J.Med.Chem., 39:3878-3881, 1996; PubMed: 8831753; DOI: 10.1021/jm960502g

実験手法

X-RAY DIFFRACTION (2 Å)