1KV1
p38 MAP Kinase in Complex with Inhibitor 1
Summary for 1KV1
Entry DOI | 10.2210/pdb1kv1/pdb |
Related | 1IAN 1KV2 |
Descriptor | p38 MAP kinase, 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA (3 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41649.99 |
Authors | Pargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J. (deposition date: 2002-01-23, release date: 2002-03-27, Last modification date: 2024-02-14) |
Primary citation | Pargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat.Struct.Biol., 9:268-272, 2002 Cited by PubMed: 11896401DOI: 10.1038/nsb770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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